Table 2.
Comparison of AS patient HLA-B27 prevalence in European and East Asian ethnicities
| Ethnicity | Male |
Female |
||
|---|---|---|---|---|
| B27 positive, % | Non-MHC, PRS (s.e.) | B27 positive, % | Non-MHC PRS (s.e.) | |
| European | 83.5 | 0.118 (0.00367) | 78.9 | 0.109 (0.00357) |
| East Asian | 93.7 | 0.0964 (0.00728) | 85.0 | 0.0859 (0.00666) |
Subjects were randomly selected from a larger case–control cohort to ensure an equal gender ratio (1:1) among both cases (n = 4872 European, 2430 East Asian) and healthy controls (n = 12 400 European, 2568 East Asian). HLA‐B27 prevalence is higher in male than female cases in both European (odds ratio 1.35, P = 4.7 × 10−5) and East Asian (odds ratio 2.64, P = 4.7 × 10−12) datasets; no difference is observed in the controls. PRSs are non‐significantly different between males and females in either ethnic group, with a trend for higher scores in males (Europeans P = 0.079; East Asians P = 0.29; two‐tailed t‐test).