Table 1.

Difference in enzymatic activity of CYPs in liver of SPF and GF male and female mice.

	SPF		GF
	Male (CONTROL)	Female	Male	Female
CYP1A1/2-like	1.000 ± 0.023	0.868 ± 0.057	1.229 ± 0.010	1.124 ± 0.045
CYP2C9-like	1.000 ± 0.017	6.254 ± 0.086 ▲	3.076 ± 0.081 ▲	9.950 ± 0.010 ▲
CYP2C19-like	1.000 ± 0.016	1.067 ± 0.011	0.740 ± 0.035	0.624 ± 0.006
CYP2D6-like	1.000 ± 0.025	1.126 ± 0.035	0.947± 0.011	1.186 ± 0.009
CYP3A4-like	1.000 ± 0.066	0.710 ± 0.040 ▼	0.300 ± 0.092▼	0.242 ± 0.046 ▼

Samples were measured in triplicates in a pooled liver microsomal fraction from 5 animals. Data represent the mean ± SD and values significantly increased (▲) or decreased (▼) relative to the control (SPF male mice) are labelled. Significantly changed values are highlighted in bold.