Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 26;2(2):fcaa086. doi: 10.1093/braincomms/fcaa086

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Cys³²-dependent CAP2 dimer is relevant for synaptic transmission potentiation upon LTP induction. (A) Electrophysiological recordings of mEPSCs before and after chemical LTP (cLTP) induction in 15 DIV hippocampal neurons. Representative mEPSC traces. (B) Differently from CTRL and shr-wt-CAP2 cells, CAP2-shRNA and CAP2-shRNA+shr-C32G-CAP2 neurons are unable to undergo cLTP. mEPSCs amplitude (normalized values): CTRL = 1 ± 0.03 (n = 18) versus cLTP: 1.26 ± 0.07 (n = 22); CAP2-shRNA: 1 ± 0.02 (n = 15) versus cLTP: 1 ± 0.02 (n = 20); shRNA+shr-wt-CAP2: 1 ± 0.04 (n = 19) versus cLTP: 1.25 ± 0.05 (n = 23); shRNA+shr-C32G-CAP2: 1 ± 0.031 (n = 18) versus cLTP: 1 ± 0.04 (n = 26). One-way ANOVA, Holm-Sidak's multiple comparisons test: P < 0.0001.