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. 2020 Oct 15;10:17457. doi: 10.1038/s41598-020-74326-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The HFD mice got TMJOA-like pathological changes and increased leptin expression compared to ND mice. (A) Histological morphology of the condylar cartilage of ND mice and HFD mice (400 ×). (B) Relative scores of HFD mice and ND mice. (C) Magnified local regions of condylar cartilage in ND mice and HFD mice. (D) Cartilage thickness of different layers in ND mice and HFD mice (T total layer, F fibrous layer, P proliferative layer, H hypertrophic layer). (E). Expression of IL-1β in the condylar cartilage of HFD mice and ND mice. (F) Immunohistochemical scores of IL-1β in ND and HFD groups. (G) Expression of MMP-3 in the condylar cartilage of HFD mice and ND mice. (H) Immunohistochemical scores of MMP-3 in ND and HFD groups. (I) Leptin expression in the condylar cartilage of HFD mice and ND mice. (J) Immunohistochemical scores of leptin in ND and HFD groups. *P < 0.05.