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. 2020 Oct 15;11(10):864. doi: 10.1038/s41419-020-03064-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The levels of PRMT5 in 88 paired laryngeal carcinoma tissues (LCT) and normal adjacent tissues (NAT). b Representative IHC staining of PRMT5 expression in paraffin-embedded normal tissues and laryngeal carcinoma with or without lymph-node metastasis. Scale bar, 50 µm. c IHC staining statistical analysis of PRMT5 in normal tissues (N, n = 88), primary LCT without (LN−, n = 30) or with (LN+, n = 28) regional lymph-node and distant metastasis (DM, n = 30). Mean + SD. d IHC staining statistical analysis of the association between PRMT5 expression status and TNM stage. e, f PRMT5 expression in eight paired laryngeal carcinoma lymph-node metastasis (MT) and adjacent primary tissues (PT) was performed by western blotting and qPCR. g PRMT5 expression was detected in LCT and NAT from GSE51986 cohort. h PRMT5 expression was detected in LCT without (LN−, n = 70) or with (LN+, n = 53) lymph-node metastasis in TCGA cohort. i, j Kaplan–Meier analysis for disease-free and overall survival of laryngeal carcinoma patients with high versus low expression of PRMT5 in our cohort. k Kaplan–Meier curves for DFS of laryngeal carcinoma patients with high versus low expression of PRMT5 in TCGA cohort. Statistical significance was assessed using a two-tailed t test. *p < 0.05, **p < 0.01, ***p < 0.001.