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. 2020 Oct 15;11:5211. doi: 10.1038/s41467-020-18957-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Interchromosomal RNA–chromatin interaction networks. Each node is a SE. Each edge is an interchromosomal interaction between two SEs. Red nodes: hub SEs. Green nodes: SEs that became hub SEs at the next time point. Yellow node: Linc607SE. The SEs that contain EC dysfunction-related genes are marked with the gene name. b, c Contact matrices between chromosome 2 (195–235 Mb) and chromosome 7 (80–120 Mb). b iMARGI derived contact matrices from the RNA (rows) to DNA (columns) in Days 0 (left), 3 (middle), and 7 (right) ECs. Blue arrow: interactions between Linc607SE and Serpine1SE established at Day 7. c Hi-C derived contact matrices. Locations of SEs, LINC00607, and SERPINE1 are marked on the left and at the bottom. Resolution = 200 kb.