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. 2020 Oct 15;10:17359. doi: 10.1038/s41598-020-71460-6

Figure 5.

Figure 5

ipRGCs demonstrated differential survival in response injury. (ac, g) OPN4 expression was observed in similar levels in control, bead injected and ONC retinas, indicating a preferential survival of these cells in response to injury. (d–-f, h) TBR2-expressing ipRGCs were significantly decreased in bead injected retinas, but not ONC retinas, compared to controls. Error bars represent S.E.M. Scale bars equal 100 µm. Statistical differences were determined using a One-way ANOVA followed by Tukey’s post hoc with 95% confidence (*p < 0.05). n = 6 retinas were analyzed per group, with 4 cross sections and numerous technical replicates per cross section. Cross sections contained both nasal and temporal parts, with technical replicates including areas from both the central and peripheral retina.