Figure 6. Removal of senescent cells reduces RANKL levels in aged bone.
Osteocyte-enriched bone shafts were isolated from 24-month-old female mice that had received vehicle, ABT-263, or PZ15227 by daily i.p. injections for 5 days. (A) Protein levels by Western blot and (B) band density quantification from 3 independent mice. (C) mRNA levels by qRT-PCR from 4 independent mice. Lines and error bars represent mean ± SD; P values by 1-way ANOVA.