Skip to main content
. 2020 Oct 13;11(41):3712–3722. doi: 10.18632/oncotarget.27759

Figure 4. Myocardial cytokines and signals in the CT26-inoculated BALB/c mice.

Figure 4

(A) Serum HMGB1. (B) HMGB1 and TNFα in myocardium. (C) Levels of proteins in the signaling pathway of HMGB1 or TNFα. The signals were standardized with the β-actin signal. (D) H9c2 cells treated with the ascites of CT26-inoculated BALB/c mice (Ascites) with or without a IKKbeta inhibitor IMD0354. Then SDS-soluble myosin light chain-2 (MYL1) measured using ELISA. Error bar, standard error of data collected from 3 mice. Significant differences were calculated using Student t-test. HMGB, high-mobility group box; TNF, tumor necrosis factor; RAGE, receptor for glycation end products; IKK, inhibitor κB kinase; pIKK, phosphorylated IKK; RelA, v-rel avian reticuloendotheliosis viral oncogene homolog A (p65); Control, no tumor control; CT26, mice inoculated with CT26 cells intraperitoneally.