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. Author manuscript; available in PMC: 2020 Oct 16.
Published in final edited form as: Bioorg Med Chem. 2010 May 25;18(14):5208–5223. doi: 10.1016/j.bmc.2010.05.057

Scheme 5.

Scheme 5.

Synthesis of 19. Reagents and conditions: (a) polystyrene-supported tosyl chloride, pyridine, CH2Cl2; (b) 52b, i-Pr2NEt, MeCN and then 4 N HCl/AcOEt (48% in two steps).