. Author manuscript; available in PMC: 2020 Oct 16.

Published in final edited form as: Bioorg Med Chem. 2010 May 25;18(14):5208–5223. doi: 10.1016/j.bmc.2010.05.057

Table 1.

Effect of the 1-N-substituent on activity profiles


Compds	R	IC₅₀ (nM) Ca assay	T_1/2 in rat liver microsomes^a (min)
2		500	NT^b
3		330	15
4		>3000	12
5		69	14
6		54	15
7		300	NT^b
1b		94	12

The data show T_1/2 after incubating with the 0.2 mg/mL rat liver microsomes.

NT: not tested.