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. Author manuscript; available in PMC: 2020 Oct 16.

Published in final edited form as: Bioorg Med Chem. 2010 May 25;18(14):5208–5223. doi: 10.1016/j.bmc.2010.05.057

Table 7.

Pharmacokinetic data for 1a, 1b, 36, 37, and 40 in rat (n = 3)

Compds	30 mg/kg, po				3 mg/kg, iv
	C_max^a (ng/mL)	T_1/2 (min)	AUC^a (ng h/mL)	BA (%)	AUC (ng)	T_1/2 (min)	CL (mL/min/mL)	V_ss (mL/kg)
1a	16.7	103	74.4	1.9	400	19.9	113	2542
1b	100	75.7	290	1.3	372	13	137	2349
36	100	205	195	ND^b	ND^b	ND^b	ND^b	ND^b
37	1900	72.7	5453	ND^b	ND^b	ND^b	ND^b	ND^b
4	7200	48.4	10,532	34.1	3091	11.1	16	145

^a

C_max and AUC are normalized to a dose of 30 mg/kg.

^b

ND: not determined.