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. Author manuscript; available in PMC: 2020 Oct 16.
Published in final edited form as: Bioorg Med Chem. 2010 May 25;18(14):5208–5223. doi: 10.1016/j.bmc.2010.05.057

Table 8.

In vitro pharmacokinetic data for 1a, 1b, 36, 37, and 40

Compds Caco-2 papp(×10−6cm/s)
 Solubility (μM) cLog Pa
A to B B to A
1a 0.15 0.27 <5 7.66
1b 1.51 2.23 14 6.46
36 0.33 0.14 <5 6.99
37 3.51 3.91 6 6.38
40 11.0 16.8 29 5.13
a

Calculated by ADMET predictor (ver. 4.0).