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Distinct classes of chromatin loops. (a-b) Micro-C maps and CTCF and Cohesin (Smc1a) ChIP-Seq shown for wt-CTCF mESCs and ΔRBRi-CTCF mESCs, illustrating Type 1 RBRi-dependent loops that can be explained by loss of CTCF/cohesin binding (a) and Type 2 RBRi-dependent loops that cannot be explained by loss of CTCF/cohesin binding (b). (c) Sketch of a role for CTCF clustering in blocking cohesin extrusion. Figures 4a-c are partially reproduced and edited from [36] with permission.
