FIG 2.

(A) The phylogenetic tree of representative betacoronavirus. Colors indicate different types of coronavirus: SARS-CoV (red), MERS-CoV (green), SARS-CoV-2 (blue), pangolin-CoV (yellow), bat CoV RaTG13 (purple). Whole-genome sequence was downloaded from NCBI and GISAID and underwent maximum-likelihood phylogenetic analyses. (B) Genome organization of three highly pathogenic coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2). The genes encoding structural proteins (spike [S], envelope [E], membrane [M], and nucleocapsid [N]) are in green. ORF 1a and ORF 1b, which encode nonstructural proteins, are in gray. The genes encoding accessory proteins are in blue.