Figure 2.

Role of miR-24 in cancer chemo- and radio- therapies. MiR-24 increased 5-FU sensitivity in both colorectal and gastric cancers. However, miR-24 decreased cisplatin sensitivity in both TSCC and breast cancer. Especially, in breast cancer, miR-24 enhanced tamoxifen senstitivy by targeting Bim. And miR-24 increased sensitivity of cancer cells to radiotherapy, and showed a dual role in chemotherapy. By targeting different targets, miR-24 increased radio-sensitivity in NPC, EC and LSCC. The pink ellipse means the protein in it functions as an onco-protein, and the blue ellipse means the protein in it functions as a tumor suppressor. DND1, dead end protein 1, a RNA-binding protein; FSCN1, fascin actin-bundling protein 1, a protein encoded by an actin-bundling protein, FSCN1, which is involved in formation of actin-based structures that contribute to cell migration. PTEN, phosphatase and tensin homolog, a well-known inhibitor of PI3K/Akt pathway; XIAP, X-linked inhibitor of apoptosis protein; FERMT1, also known as KINDLIN-1, is a FERM domain containing adaptor protein that is found predominantly at cell-extracellular matrix adhesions where it binds to integrin β subunits and is required for efficient integrin activation; SP1, specificity protein 1; Jab1, Jun activation domain-binding protein 1, an onco-protein.