Table 2.
CMC of APLs and CAC of pro-APLs as measured using a fluorescent probe technique.
| Compound | CAC (μM) | Compound | CAC (μM) | Compound | CAC (μM) |
|---|---|---|---|---|---|
| Miltefosine | 11.2 ± 2.3 | Perifosine | 4.4 ± 1.7 | Erufosine | 1.6 ± 0.5 |
| M12 | 1.1 ± 0.6 | P12 | 1.2 ± 0.4 | E12 | 0.7 ± 0.3 |
| ME12 | 4.3 ± 2.5 | PE12 | 2.9 ± 1.0 | EE12 | 0.6 ± 0.2 |
| M | 1.3 ± 0.7 | P | 2.3 ± 1.4 | E | 1.1 ± 0.7 |
| MC12 | 4.1 ± 2.5 | PC12 | 4.5 ± 1.6 | EC12 | 1.2 ± 0.2 |
| M | 2.0 ± 0.7 | P | 3.3 ± 0.7 | E | 0.9 ± 0.2 |
| MC18:1 | 0.9 ± 0.4 | PC18:1 | 2.3 ± 1.0 | EC18:1 | 0.8 ± 0.4 |
Data for erufosine and erufosine prodrugs are reported from the literature (Gaillard et al., 2019).