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. 2020 Oct 2;8:581260. doi: 10.3389/fchem.2020.581260

Table 2.

CMC of APLs and CAC of pro-APLs as measured using a fluorescent probe technique.

Compound CAC (μM) Compound CAC (μM) Compound CAC (μM)
Miltefosine 11.2 ± 2.3 Perifosine 4.4 ± 1.7 Erufosine 1.6 ± 0.5
M12 1.1 ± 0.6 P12 1.2 ± 0.4 E12 0.7 ± 0.3
ME12 4.3 ± 2.5 PE12 2.9 ± 1.0 EE12 0.6 ± 0.2
M E12 1.3 ± 0.7 P E12 2.3 ± 1.4 E E12 1.1 ± 0.7
MC12 4.1 ± 2.5 PC12 4.5 ± 1.6 EC12 1.2 ± 0.2
M C12 2.0 ± 0.7 P C12 3.3 ± 0.7 E C12 0.9 ± 0.2
MC18:1 0.9 ± 0.4 PC18:1 2.3 ± 1.0 EC18:1 0.8 ± 0.4

Data for erufosine and erufosine prodrugs are reported from the literature (Gaillard et al., 2019).