FIGURE 2.

Practical algorithm for switching between once-daily and once-weekly GLP-1 receptor agonist therapies. *First dose of 7 or 14 mg to be administered 1–7 days after last injection (based on limited advice in the prescribing information, which specifies only when switching from semaglutide 0.5 mg subcutaneous). †Assessment of equivalent dose is entirely based on authors’ opinion, which in turn is based on head-to-head clinical trials when available and/or clinical experience. Other reasons for switching could include patient preference, concern about drug interactions, and cost/insurance issues. Exenatide once weekly is not available at a lower dose but could be tried if this is an insurance-preferred GLP-1 receptor agonist. BID, twice daily; GLP-1RA, GLP-1 receptor agonist; QD, once daily; QW, once weekly.