TABLE 2.
Clinical and molecular characteristics of TCGA HCC patients according to the mutation/CNV status of m6A regulatory genes.
| With mutation and/or CNV | Without mutation or CNV | P-value | ||
| Age | ≤60 | 65 | 110 | 0.8699 |
| >60 | 69 | 121 | ||
| Gender | male | 106 | 142 | 0.0005 |
| female | 28 | 89 | ||
| Histological grade | G1 | 13 | 37 | 0.3807 |
| G2 | 66 | 111 | ||
| G3 | 48 | 72 | ||
| G4 | 5 | 8 | ||
| Pathological stage | I | 66 | 106 | 0.4808 |
| II | 35 | 50 | ||
| III | 24 | 56 | ||
| IV | 2 | 3 | ||
| T stage | T1 | 69 | 113 | 0.6385 |
| T2 | 36 | 57 | ||
| T3 | 24 | 51 | ||
| T4 | 3 | 9 | ||
| Tx | 1 | 0 | ||
| N stage | N0 | 93 | 158 | 0.3010 |
| N1 | 0 | 3 | ||
| Nx | 40 | 70 | ||
| M stage | M0 | 98 | 165 | 0.5584 |
| M1 | 2 | 1 | ||
| Mx | 34 | 65 | ||
| TP53 | alteration | 55 | 65 | 0.0114 |
| wt | 79 | 166 |
With mutation and/or CNV: cases have mutation or CNV or mutation + CNV. Without mutation or CNV: cases with neither mutation nor CNV. Ambiguous variables (Tx, Nx, and Mx) were excluded from chi-square test or Fisher’s exact test. Significant P values are in bold.