TABLE 1.

Global hemodynamic changes during the experiment.

Variables	Baseline*	1 h	2 h	3 h	4 ha	Time interaction	Group interaction	Group and time interaction
CO, l/min
SHAM	0.49 ± 0.06	0.51 ± 0.03	0.54 ± 0.03	0.58 ± 0.05	0.59 ± 0.10	0.057	vs. EDX†	<0.001
EDX	0.54 ± 0.06	0.56 ± 0.07	0.70 ± 0.07	0.83 ± 0.07	0.81 ± 0.09	<0.001	vsEDX-R†
EDX-R	0.51 ± 0.08	0.61 ± 0.10	0.77 ± 0.07	0.99 ± 0.14	1.04 ± 0.12	< 0.001	vsSHAM†
SV, ml
SHAM	2.7 ± 0.4	2.7 ± 0.3	2.9 ± 0.4	3.1 ± 0.4	3.0 ± 0.6	0.176		0.147
EDX	3.0 ± 0.5	2.8 ± 0.5	3.2 ± 0.7	3.5 ± 0.8	3.5 ± 0.7	0.060
EDX-R	3.0 ± 0.4	3.4 ± 0.5	3.6 ± 0.5	4.3 ± 0.6	4.1 ± 0.6	0.005
SAP, mmHg
SHAM	87 ± 13	76 ± 8	69 ± 10	65 ± 7	61 ± 6	0.010	vs. EDX†	<0.001
EDX	82 ± 11	62 ± 11	50 ± 11	42 ± 4	42 ± 5	0.002	vs. EDX-R†
EDX-R	85 ± 13	61 ± 11	57 ± 7	50 ± 8	77 ± 10	< 0.001	vsSHAM
DAP, mmHg
SHAM	53 ± 6	46 ± 6	43 ± 7	40 ± 4	38 ± 3	0.006	vs. EDX†	<0.001
EDX	48 ± 6	41 ± 7	32 ± 6	27 ± 3	26 ± 3	0.007	vs. EDX-R
EDX-R	48 ± 7	37 ± 5	35 ± 3	29 ± 3	47 ± 6	<0.001	vsSHAM†
MAP, mmHg
SHAM	63 ± 7	55 ± 6	51 ± 8	47 ± 5	46 ± 3	0.006	vs. EDX†	<0.001
EDX	57 ± 7	47 ± 8	38 ± 8	34 ± 1	30 ± 3	0.007	vs. EDX-R†
EDX-R	58 ± 8	45 ± 7	42 ± 4	38 ± 3	59 ± 5	<0.001	vsSHAM†

Data are presented as mean ± standard deviation. CO, cardiac output; DAP, diastolic arterial pressure; HR, heart rate; MAP, mean arterial pressure; SAP, systolic arterial pressure; SV, stroke volume; SHAM, sham-operated group; EDX, non-resuscitated septic rabbits; EDX-R, resuscitated septic rabbits. ^∗Baseline values were similar between different experimental groups. ^aIn the EDX-R group, 4h refers after both fluid bolus and norepinephrine infusion. ^†p < 0.05 for between-group effects (Tukey-Kramer).