TABLE 4.
Mixed-effects regression model for the interaction between Eadyn and arterial load, cardiac, cardiac energetics and cardiovascular efficiency indexes in endotoxic shock animals (EDX and EDX-R groups).
| Fixed effects | β estimate | 95% confidence interval | p-value |
| Arterial load variables | |||
| SVR, dyn⋅s⋅cm–5⋅103 | 0.009 | −0.056 to 0.075 | 0.770 |
| C, ml/mmHg | 0.509 | −1.534 to 2.552 | 0.611 |
| Zc, dyn⋅s⋅cm–5⋅103 | −1.053 | −1.896 to −0.209 | 0.017 |
| Cardiac related variables | |||
| Heart rate, beats/min | 0.006 | 0.003 to 0.008 | 0.002 |
| Accel, ms/s2 | 0.047 | −0.044 to 0.137 | 0.101 |
| PV, m/s | −0.010 | −0.050 to 0.029 | 0.599 |
| Cardiac energetics variables | |||
| Ẇstd, W | 0.017 | 0.007 to 0.027 | <0.001 |
| Ẇosc, W | −0.125 | −0.174 to −0.076 | <0.001 |
| Cardiovascular efficiency variables | |||
| %Osc | −0.101 | −0.137 to −0.064 | <0.001 |
| EER, W⋅s⋅ml–1 | −9.494 | −11.964 to −7.024 | <0.001 |
Accel, maximal acceleration of aortic blood flow; C, arterial compliance; Eadyn, dynamic arterial elastance; EER, energy efficiency ratio; PV, peak velocity of aortic blood flow; SVR, systemic vascular resistance; Ẇosc, left ventricular oscillatory work; Ẇstd, left ventricular steady work; Zc, characteristic impedance; %Osc, oscillatory power fraction. Estimates reflect the average change in Eadyn per unit increase of the fixed effect. Mixed-effect regression models were constructed using arterial variables (SVR, C and Zc), cardiac variables (HR, Accel and PV), cardiac energetic variables (Ẇstd and Ẇosc), and cardiovascular efficiency indexes (%Osc and EER) as independent variables.