Figure 1.

Site-specific map of the human serum glycome. The major glycans occurring at the glycosylations sites of the 17 most common serum glycoproteins are presented. When present, the sites of glycosylation (first of the two numbers) are as indicated in UNIPROT. When there is no position indicated, the glycosylation occurs at the immunoglobulin constant heavy chain domain 2 (CH2)-84.4 glycosylation site (IMGT numbering system). Glycan structures are presented as a four digit code where the first numeral represents the total number of mannose and galactose residues combined, the second represents the total number of N-acetylglucosamine residues, the third numeral corresponds to the number of fucose residues, and the final numeral is the number of sialic acid moieties. On the right side of each diagram is the log of the relative abundances of the glycans presented as box-and-whisker plots. The left and right bars connected to each box indicate the boundaries of the normal distribution and the left and right box edges mark the first and third quartile boundaries within each distribution. The bold line within the box indicates the median value of the distribution. On the left of each diagram are the square of the intra-protein Pearson Product Moment Correlation Coefficients (PPMCCs) for connected glycan pair.