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. 2020 Oct 15;11:5214. doi: 10.1038/s41467-020-19055-7

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Three-day cytotoxicity of chloroquine on Vero E6 and A549-hACE2 cells. b Three-day cytotoxicity of remdesivir on Vero E6 and A549-hACE2 cells. c EC₅₀ of chloroquine against SARS-CoV-2-Nluc on Vero E6 and A549-hACE2 cells. d EC₅₀ of remdesivir against SARS-CoV-2-Nluc on Vero E6 and A549-hACE2 cells. a–d Experiments were performed at least twice. Each time, two independent assays were performed. The plots show one of the two experiments performed in duplicates. Each replicate is shown. The four-parameter dose–response curve was fitted using the nonlinear regression method and EC₅₀s were calculated in the software Prism 8. e Summary of CC₅₀, EC₅₀, and selectivity index (SI). The mean ± standard deviations from four independent experiments are indicated. SI = CC₅₀/EC₅₀.