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. 2020 Oct 15;3:573. doi: 10.1038/s42003-020-01302-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Patient characteristics. Histogram of LVEFs for the patients under study (n = 15). Chronic cardiotoxic patients (dark blue) and control cardiomyopathy patients (light blue) are sorted after LVEF. b LVEF (X-axis) of chronic cardiotoxic patients decreases with duration of chemotherapy in days (Y-axis); color of the nodes correspond to LVEF classification of the respective patient. c Examples of in vitro-derived ACT response proteins whose expression in biopsies of cardiotoxic patients correlate with LVEF. X-axes shows LVEF, Y-axis shows normalized protein expression. Color of the nodes correspond to LVEF status similar to b. d Discordant correlation values of biopsies protein expression with the LVEFs of the two patient groups. Blue bars: correlation with respect to cardiotoxic patients, red bars: control group. X-axis: genes, Y-axis: correlation values (range [−1,1]). e Pairwise comparison of protein expression fold-changes of measured time points (8, 24, 72, 168, 240, and 336 h) against the earliest time point (2 h) in 3D cardiac microtissues using Student’s t-test on n = 3 experimental replicates. Y-axis: bars indicate log2-fold change. Colors of the bars indicate significance of fold-change (dark blue: Q < 0.05; light blue: Q ≥ 0.05).