Figure 1.

The effect of surgery on plasma metabolites in wasting and non‐wasting patients. (A) Principal component analysis of all metabolites shows clear separation of the metabolic profiles into three groups: before surgery (Day 0) 24 h post‐surgery (Day 1) and a cluster containing both Days 3 and 7 post‐surgery. (B) Two‐way ANOVA comparing the effect of time and phenotype (wasting vs. non‐wasting patients) on plasma metabolites; 488 metabolites were different as a function of time alone, 36 differed as a function of phenotype with 69 metabolites altered as a function of both time and phenotype.