Table 3.
Lipids elevated more than three‐fold on Day 1 after surgery compared with Day 0 arranged by fold increase
| Metabolite | Pathway/type | P (adjusted) | Fold change Day 1 | Fold change Day 3 | Fold change Day 7 |
|---|---|---|---|---|---|
| Tetrahydrocortisol sulfate | Corticosteroids | 7.3E‐05 | 17.69 | 14.16 | 3.00 |
| 17alpha‐Hydroxypregnanolone glucuronide | Pregnenolone steroids | 7.0E‐03 | 15.16 | 7.25 | 4.40 |
| Beta‐sitosterol | Sterol | 2.2E‐03 | 11.21 | 8.25 | 3.28 |
| Estrone 3‐sulfate | Estrogenic steroids | 8.9 E‐07 | 10.99 | 12.10 | 1.50 |
| Palmitoyl‐arachidonoyl‐glycerol (16:0/20:4)1 * | Diacylglycerol | 2.9 E‐02 | 7.90 | 2.54 | 24.28 |
| 5alpha‐Pregnan‐diol disulfate | Progestin steroids | 1.0 E‐03 | 7.01 | 2.41 | 1.22 |
| 2‐hydroxyadipate | Dicarboxylate | 4.1 E‐02 | 5.70 | 4.33 | 6.54 |
| Adipoylcarnitine (C6‐DC) | Acyl carnitine | 1.4 E‐06 | 5.04 | 4.52 | 3.25 |
| Taurocholate | Primary Bile Acid | 7.2 E‐07 | 4.68 | 345.54 | 194.49 |
| Suberoylcarnitine (C8‐DC) | Acyl carnitine | 2.7 E‐04 | 3.99 | 4.40 | 3.33 |
| Pregnenolone sulfate | Pregnenolone steroids | 1.8 E‐04 | 3.57 | 1.08 | 1.01 |
| Arachidonoylcholine | Acyl choline | 2.3 E‐03 | 3.54 | 2.69 | 11.21 |
| 3,4‐Methyleneheptanoylcarnitine | Acyl carnitine | 4.2 E‐02 | 3.49 | 1.72 | 1.38 |
| Myo‐inositol | Inositol | 3.6 E‐09 | 3.23 | 1.94 | 1.07 |
| Pregnenediol sulfate (C21H34O5S)* | Pregnenolone steroids | 8.6 E‐05 | 3.08 | 1.44 | 0.79 |
| Taurodeoxycholate | Bile acid | 6.8 E‐06 | 3.05 | 111.00 | 126.14 |
| Cortisol | Corticosteroids | 1.5 E‐08 | 3.00 | 2.50 | 2.49 |
A two‐way ANOVA was performed on log‐transformed data in Metaboanalyst as described in Methods. Fold change was calculated on unlogged data. C(x) refers to carbon chain length; DC, dicarboxylate;
*
metabolite identification by mass spectrum only.