Table 3.
Association of muscle and adipose tissue tertiles with overall mortality using ABACS and manual analysis to assess body composition: C‐SCANS non‐metastatic colorectal patients and B‐SCANS breast cancer patients (n = 5990) a , b
| C‐SCANS (n = 3102) c | B‐SCANS (n = 2888) d | |||||||
|---|---|---|---|---|---|---|---|---|
| Events | ABACS | Events | Manual analysis | Events | ABACS | Events | Manual analysis | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |||||
| Skeletal muscle | ||||||||
| Tertile 1 | 339 | 1.23 (1.00, 1.52) | 342 | 1.38 (1.11, 1.70) | 212 | 1.30 (1.01, 1.66) | 207 | 1.29 (1.00, 1.65) |
| Tertile 2 | 250 | 1.01 (0.84, 1.23) | 260 | 1.16 (0.96, 1.41) | 159 | 0.95 (0.76, 1.19) | 172 | 1.01 (0.81, 1.27) |
| Tertile 3 (Ref.) | 222 | 1.0 (—) | 209 | 1.0 (—) | 176 | 1.0 (—) | 168 | 1.0 (—) |
| Continuous, per SD e | 811 | 0.86 (0.75, 0.98) | 811 | 0.74 (0.65, 0.86) | 547 | 0.89 (0.80, 0.99) | 547 | 0.89 (0.80, 1.00) |
| Subcutaneous adipose | ||||||||
| Tertile 1 (Ref.) | 293 | 1.0 (—) | 294 | 1.0 (—) | 174 | 1.0 (—) | 174 | 1.0 (—) |
| Tertile 2 | 263 | 0.96 (0.80, 1.15) | 262 | 0.93 (0.77, 1.11) | 174 | 1.04 (0.82, 1.32) | 176 | 1.01 (0.80, 1.28) |
| Tertile 3 | 255 | 0.98 (0.80, 1.21) | 255 | 0.97 (0.79, 1.19) | 199 | 1.28 (0.99, 1.67) | 197 | 1.24 (0.95, 1.62) |
| Continuous, per SD | 811 | 0.99 (0.91, 1.08) | 811 | 0.97 (0.88, 1.07) | 547 | 1.12 (1.01, 1.23) | 547 | 1.09 (0.98, 1.22) |
| Visceral adipose | ||||||||
| Tertile 1 (Ref.) | 283 | 1.0 (—) | 277 | 1.0 (—) | 156 | 1.0 (—) | 151 | 1.0 (—) |
| Tertile 2 | 242 | 0.78 (0.65, 0.93) | 246 | 0.82 (0.68, 0.99) | 174 | 0.84 (0.66, 1.06) | 180 | 0.92 (0.72, 1.17) |
| Tertile 3 | 286 | 0.93 (0.76, 1.14) | 288 | 0.99 (0.81, 1.22) | 217 | 0.98 (0.75, 1.28) | 216 | 1.03 (0.78, 1.36) |
| Continuous, per SD | 811 | 1.01 (0.92, 1.10) | 811 | 1.07 (0.97, 1.18) | 547 | 1.01 (0.91, 1.13) | 547 | 1.04 (0.93, 1.16) |
Tertiles are defined separately by cancer site (colorectal versus breast), sex (male versus female among colorectal cancer patients only), and data source (ABACS automated versus manual analysis).
Cox proportional hazards models mutually adjust muscle, subcutaneous and visceral adipose tissue tertiles, and additionally adjust for age, sex, race/ethnicity, stage and grade, receipt of chemotherapy and/or radiation, smoking status.
Models for overall survival after colorectal cancer additionally adjust for tumour site (colon versus rectum).
Models for overall survival after breast cancer additional adjust for hormone receptor and HER2 status.
SD = standard deviation units defined by dividing the individual patient's value for each tissue area by the population standard deviation for that tissue.