Table 4.

The role of Tripterygium ingredients for DCs.

Component	Models	Molecular mechanism	Effects	Animal disease phenotype	Ref.
Duantengyimu decoction	GM-CSF and IL-4 stimulate PBMCs isolated from patients with RA	NA	Decrease the expression of CCR5 and CCR7, decrease the secretion of CXCL9 and CXCL10, and inhibit the migration of DC	NA	(Sun, 2017)
Tripterygium Wilfordii Saponins	GM-CSF, TNF-α, and IL-4 stimulate PBMCs	NA	Inhibit the expressions HLA-DR and CD80 on the membrane. Decrease the synthesis of IL-12 p40 subunit	NA	(Wang et al., 2001)
Tripterygium glycosides	DCs isolated from rats	NA	Reduce the expression of MHC-II, CD80, CD86, and CD40 on the membrane of DC	NA	(Chen et al., 2006)

TP, Triptolide; Caspase, Aspartic acid protease containing cysteine; CCR, Chemokine receptor; CXCL, C-X-C motif chemokine ligand; MAP, Mitogen activated protein; MHC, Major histocompatibility complex.