Figure 4.

Effect of eslicarbazepine acetate and S-licarbazepine on the current-voltage relationship. (A) Current-voltage (I–V) plots of Na⁺ currents in MDA-MB-231 cells in physiological saline solution (PSS; black circles) and in eslicarbazepine acetate (ESL; 300 μM; red squares). (B) (I–V) plots of Na⁺ currents in HEK-Na_v1.5 cells in PSS (black circles) and ESL (300 μM; red squares). (C) I–V plots of Na⁺ currents in MDA-MB-231 cells in PSS (black circles) and S-licarbazepine (S-Lic; 300 μM; red squares). (D) I–V plots of Na⁺ currents in HEK-Na_v1.5 cells in PSS (black circles) and S-Lic (300 μM; red squares). Currents were elicited using 10 mV depolarising steps from -80 to +30 mV for 30 ms, from a holding potential of -120 mV. Results are mean ± SEM (n = 7–13).