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. 2020 Oct 2;11:555047. doi: 10.3389/fphar.2020.555047

Figure 6.

Figure 6

Effect of eslicarbazepine acetate and S-licarbazepine on recovery from inactivation. (A) Recovery from inactivation in MDA-MB-231 cells in physiological saline solution (PSS; black circles) and in eslicarbazepine acetate (ESL; 300 μM; red squares). (B) Recovery from inactivation in HEK-Nav1.5 cells in PSS (black circles) and ESL (300 μM; red squares). (C) Recovery from inactivation in MDA-MB-231 cells in PSS (black circles) and S-licarbazepine (S-Lic; 300 μM; red squares). (D) Recovery from inactivation in HEK-Nav1.5 cells in PSS (black circles) and S-Lic (300 μM; red squares). The fraction recovered (It/Ic) was determined by a 25 ms pulse to 0 mV (Ic), followed by a recovery pulse to -120 mV for 1–500 ms, and a subsequent 25 ms test pulse to 0 mV (It), applied from a holding potential of -120 mV, and plotted as a function of the recovery interval. Data are fitted with single exponential functions which are statistically different between control and drug treatments in all cases. Results are mean ± SEM (n = 7–10).