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. 2020 Oct 2;11:555047. doi: 10.3389/fphar.2020.555047

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Copyright © 2020 Leslie, Brückner, Chawla and Brackenbury

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustal alignment of amino acid sequences of Na_v1.1-Na_v1.9 (SCN1A-SCN11A). ESL was proposed previously (Shaikh et al., 2014) to interact with the highlighted amino acids in Na_v1.2. An alignment of Na_v1.2 [UniProtKB - Q99250 (SCN2A_HUMAN)] with Na_v1.1 [UniProtKB - P35498 (SCN1A_HUMAN)], Na_v1.3 [UniProtKB - Q9NY46 (SCN3A_HUMAN)], Na_v1.4 [UniProtKB - P35499 (SCN4A_HUMAN)], Na_v1.5 [UniProtKB - Q14524 (SCN5A_HUMAN)] Na_v1.6 [UniProtKB - Q9UQD0 (SCN8A_HUMAN)], Na_v1.7 [UniProtKB - Q15858 (SCN9A_HUMAN)], Na_v1.8 [UniProtKB - Q9Y5Y9 (SCN10A_HUMAN)], and Na_v1.9 [UniProtKB - Q9UI33 (SCN11A_HUMAN)] shows that the interacting amino acids highlighted in yellow are conserved between Na_v1.2 and Na_v1.5, along with most other isoforms. Asterisks indicate conserved residues. Colon indicates conservation between groups of strongly similar properties - scoring >0.5 in the Gonnet PAM 250 matrix. Period indicates conservation between groups of weakly similar properties - scoring ≤0.5 in the Gonnet PAM 250 matrix.