Table 2. Characteristics of participant groups.
| Characteristics | CN (n = 136) | SMC (n = 46) | eMCI (n = 83) | MCI (n = 37) | lMCI (n = 46) | ADD (n = 35) | P-value (ANOVA or chi-square) |
|---|---|---|---|---|---|---|---|
| Age, mean (SD), y | 74.5 (7.1) | 75.3 (5.8) | 74.5 (7.0) | 74.3 (7.2) | 74.6 (6.8) | 75.6 (6.8) | 0.93 |
| Female sex, No. (%) | 82(60) | 26(57) | 42 (51) | 15 (41) | 21 (46) | 16 (46) | 0.22 |
| Handedness, No. (%) | 126 (92) | 42 (91) | 76 (92) | 34 (92) | 42 (91) | 33 (94) | 0.99 |
| Education, mean (SD), y | 16.8 (2.3) | 16.8 (2.6) | 16.0 (2.7) | 16.3 (2.5) | 16.4 (2.9) | 16.2 (2.7) | 0.23 |
| Scanner vendor (S:G:P) | 86:27:24 | 18:15:13 | 31:11:41 | 18:9:10 | 19:6:21 | 6:3:26 | <0.001 |
| Brain volume (SD) X105 | 10.6 (0.9) | 10.7 (0.9) | 10.6 (2.2) | 10.4 (1.0) | 10.4 (1.1) | 10.2 (1.2) | 0.41 |
| MMSE score, mean (SD) | 29.1 (1.7) | 29.1 (1.0) | 27.4 (2.9) | 28.0 (1.5) | 25.8 (5.6) | 22.4 (3.2) | <0.001 |
| CDR global score, mean (SD) | 0.0 (0.2) | 0.1 (0.2) | 0.4 (0.3) | 0.5 (0.0) | 0.6 (0.5) | 0.8 (0.2) | <0.001 |
| CDR-SOB score, mean (SD) | 0.3 (1.0) | 0.1 (0.4) | 1.7 (2.2) | 1.2 (0.8) | 2.6 (3.2) | 4.7 (1.5) | <0.001 |
| GDS score, mean (SD) | 0.8 (1.5) | 1.3 (1.3) | 1.8 (2.0) | 1.5 (1.3) | 1.8 (2.3) | 1.5 (1.3) | <0.001 |
| FAQ score, mean (SD) | 1.0 (3.7) | 0.4 (0.8) | 4.2 (6.5) | 3.1 (4.4) | 6.5 (8.7) | 14.6 (6.2) | <0.001 |
| WMS-LMII score, mean (SD) | 15.4 (3.3) | 15.4 (3.0) | 12.4 (5.1) | 9.2 (3.8) | 9.7 (5.0) | 4.5 (3.1) | <0.001 |
| ADAS-Cog score, mean (SD) | 9.6 (4.4) | 8.2 (3.1) | 12.0 (6.0) | 12.3 (3.4) | 14.0 (8.3) | 22.7 (7.4) | <0.001 |
| Hachinski scale, mean (SD) | 0.5 (0.7) | 0.6 (1.0) | 1.0 (1.2) | 0.8 (1.2) | 0.7 (0.9) | 0.9 (0.9) | 0.25 |
Note: S = Siemens; G = GE Medical Systems; P = Philips Medical System and Philips Healthcare.