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. 2020 Aug 15;11(1):1024–1040. doi: 10.1080/21505594.2020.1804275

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© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Vaccination with PIV5-Pal_Bm provides protection against challenge with a lethal dose of WT B. mallei. BALB/c mice vaccinated intranasally with PIV5 viruses were challenged with 10 LD₅₀ of B. mallei ATCC 23344 using a Microsprayer device and monitored daily for clinical signs of illness and morbidity. (a) Kaplan-Meier survival curves. (b) Survival data during the acute (days 1 through 10 post-challenge) and chronic (days 11 through 40 post-challenge) phases of infection. (c–e) At study end-points, tissues collected from survivors were homogenized, diluted, and spread on agar plates to determine bacterial loads. Symbols represent individual animals; horizontal lines show the mean total CFU for each group. The asterisks indicate that the survival curves were found to be significantly different from mice vaccinated with PBS and the control vaccine PIV5-Tb. The hashtags indicate that the decrease in bacterial burden, compared to mice vaccinated with PIV5-BatA, is statistically significant. Although a 30-fold decrease in lung bacterial burden was observed between mice vaccinated with PIV5-Pal_Bm and PIV5-BatA, this decrease was not statistically significant (panel C).