Figure 4.
METTL3mediates gene and protein expression of CCND1 in an m6A-dependent manner.
(a) Methylated RNA immunoprecipitation (MeRIP)-qPCR analysis of m6A levels of CCND1 mRNA in each group after MDI-induced for 24 h. (b) Western blot analysis of METTL3 and CCND1 in cells after transfected with control, wild-type (WT) and mutant (MUT) METTL3 plasmid and MDI-induced for 24 h. The data are presented as the mean ± SD of triplicate tests. *P< 0.05, **P< 0.01, ***P< 0.001 compared to the control group.