Figure 2.

LncRNAs regulate p53 activity. Several lncRNAs, some themselves regulated by p53 modulate the p53-response by multiple mechanisms including, destabilizing p53-interactions with its negative regulator MDM2 (MEG3, PSTAR), increasing p53 levels by increased translation (MT1JP), phosphorylation of p53 (LOC572558) or direct interactions with p53 to stabilize the protein (DINO), and downregulate p53 levels via miRNAs or reduced the transcript stability (LincRNA-ROR, H19) or downregulating p53 acetylation and stabilization (MALAT1).