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General principles and mechanisms underlying ncRNA functions. A. ncRNAs interact with diverse partners. B. LncRNAs counter regulate miRNAs by: i) modulating pre-miRNA processing, ii) direct sequestration, iii) competition for same target RNAs. C. LncRNAs regulate gene expression by i) modulating chromatin architecture of nearby genes in cis; ii) complexing with transcription factors or iii) forming RNA-DNA duplexes to regulate transcription of distal genomic loci.
