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. 2019 Dec 26;17(11):1628–1635. doi: 10.1080/15476286.2019.1705610

Figure 2.

Figure 2.

LncRNAs as positive and negative regulators of inflammation. A. Different lncRNAs recruit distinct partner proteins to regulate inflammatory cytokine expression. Il6 transcription is augmented by lincRNA-Cox2 and lncRNA NEAT1. TNF expression is upregulated by lncRNA THRIL. Transcription of the Ifng locus is regulated by lncRNA NeST. B. In humans, Il6 transcription is negatively regulated by Lnc-17R and ROCKI. In mice, Il6 transcription is negatively regulated by lncRNA Mirt2 and Lethe. Lnc13 interacts with hnRNPL to block the transcription of Tnf. LncRNA-CD244 recruits EZH2 to deposit repressive histone marks and shut down transcription at both the TNF and IFNG loci.