Figure 1.

Association with transcriptional factors (TFs).

lncRNAs regulate gene transcription via influencing on TFs. (a) RNA guide: An lncRNA interacts with a single TF directly or indirectly and recruits the TF to the target gene promoters. (b) Molecular scaffold: An lncRNA is able to interact with multiple transcriptional regulators and promotes their recruitment to the target gene’s promoter. (c) RNA decoy: An lncRNA sequesters its associated TF from the target gene’s promoter or the latter’s complex.