Table 4.

Facilitating chromosomal looping.

lncRNAs	Cancer type	Functions and phenotype	References
IRAIN	acute myeloid leukaemia	Interacts with chromatin DNA, forming an intra-chromosomal enhancer/promoter loop to down-regulate the expression of IGF1R.	[116]
Khps1	Osteosarcoma	Forms a RNA-DNA triplexes via a homopurine stretch upstream of the transcription start site of SPHK1, recruits p300/CBP and E2H1 to the SPHK1 promoter, and mediate the chromatin structure change of the target regions. It acts as an oncogenic molecule by up-regulating its deriving gene SPHK1’s expression.	[118]
CCAT1-L	Colorectal cancer	Forms chromatin looping between the MYC enhancer and promoter, recruits CTCF to regulate MYC expression.	[119]