Table 5.

Interaction with RNA polymerase.

lncRNAs	Cancer type	Functions and phenotype	References
SLERT	Teratoma	Interacts with single DDX21 molecule to adjust the size of the DDX21 ring and relieve the inhibition of pol I, activates pol I -mediated transcription initiation directly and promote tumorgenesis.	[122]
lncRNA AY	Hepatocellular carcinoma	Interacts with histone 1FX (H1FX) to the ITGAV promoter, enhances modification of H3K4Me3 and acH3K9/14 but reduces H3K27Me3 modification and H1FX occupation on ITGAV promoter. This causes a change of chromatin structure and pol II recruitment to target gene promoter for gene activation.	[125]
NRCP	Ovarian cancer	Recruits both TF (STAT1) and RNA polymerase II as an intermediate to target gene’s promoter. The complex then increases the expression of downstream genes including glucose-6-phosphate isomerase to modulate cancer metabolism and promote ovarian cancer development.	[128]