Figure 4.

2ʹ-O-methylated rRNA showed direct correlation to cancer progression while pseudouridine modification was reported to have a negative correlation with cancer progression. (A) FBL regulates the methylation on rRNA leading to the upregulation of IRES-containing oncogenic transcripts, but has limited effects on m⁷G cap-dependent translation. (B) Pseudouridine on rRNA is regulated by DKC1. The knockdown DKC1 gene downregulates tumour suppressor proteins (P53 and P27) while upregulates the translation of VEGF. (C) The ribosomal protein complex with 5S-rRNA (IRBC) to regulate tumour proliferation by binding to HDM2 of the p53-HDM2 complex [220].