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. 2020 Oct 14;9(1):1831153. doi: 10.1080/2162402X.2020.1831153

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — BMS1166 relieved immune suppression and activated T cell. (a) Schematic diagram of luciferase reporter gene assay. NFAT-RE, NFAT response elements. (b) and (c) PC9/PD-L1 cells were incubated with DMSO or 10 μM BMS1166 for 17 hr, and then cocultured with NFAT-luc-expressing Jurkat/PD-1 cells (b) or Jurkat/PD-1 cells (c) for 12 hr by concomitant treatment of 1 μM INM plus 10 ng/ml TPA. Cell lysates were collected to react with luciferase substrates (b) or analyzed by RT-qPCR. **, P < .01; ***, P < .001; ****, P < .0001, Student’s t test. Error bars, mean ± SD.