Table 3.
Kinetic Analysis of Release Models of VRC from Control (CL) and the Prepared Selected Niosomal Formula F7 at pH 7.4 Containing 0.25% w/w Tween 80
| Formula Code | Correlation Coefficient (R2) | Release Mechanism |
Korsmeyer –Peppas | Main Transport Mechanism | |||
|---|---|---|---|---|---|---|---|
| Zero Order | First Order | Higuchi Model | R2 | N | |||
| CL | 0.4280 | 0.5554 | 0.6925 | Diffusion | 0.8643 | 0.53 | Non-Fickian |
| F7 Susp | 0.7380 | 0.6830 | 0.9180 | Diffusion | 0.9394 | 0.48 | Non-Fickian |
| F7 Ocu | 0.8874 | 0.9546 | 0.9899 | Diffusion | 0.9639 | 0.56 | Non-Fickian |
| D Ocu | 0.7261 | 0.8031 | 0.9225 | Diffusion | 0.9579 | 0.37 | Fickian |
Notes: D ocu, Ocular inserts containing free drug; R2, Linear correlation coefficient; n, Diffusional exponent revealing of the drug release mechanism (slope).
Abbreviations: CL, control-free drug suspension; ocu, ocular insert.