Fig. 2. 3D rendering of significant volume reduction in EC-Tau mice in the MTL at 20 to 24 months old (which represents an early stage in human AD tauopathy) and 30 to 36 months old (which represents a moderate stage).

TBM-related atrophy in the EC and hippocampus at (A) early stage and (B) moderate stage. For each panel, the colored regions depict the EC (LEC and MEC) in blue and the hippocampus (DG, CA1, CA2, CA3, and dhc; subicular complex: Sub, PPS, and Post) in green. Each panel shows the top view (left), left hemisphere (middle), and right hemisphere (right) of the mouse brain. Voxel-based analyses were conducted using a general linear model in statistical parametric mapping (SPM), and individual genotypes at each stage were contrasted using two-sample Student’s t test. Statistics are represented as heatmaps of t values corresponding to voxel-level P < 0.005 and cluster-level P < 0.05.