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. 2020 Oct 16;6(42):eabc8098. doi: 10.1126/sciadv.abc8098

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 5 — (A) Representative model of the left hemisphere of the mouse brain with the EC (LEC and MEC) in blue and the hippocampus (DG, CA1, CA2, CA3, and dhc; subicular complex: Sub, PPS, and Post) in green. iDISCO+ CP27 (white), which stains all human tau, was coregistered with TBM-related atrophy at (B) the early stage and (C) the moderate stage. Each panel shows the top view (left) and left hemisphere (right) of the mouse brain. Voxel-based analyses were conducted using a general linear model in SPM, and individual genotypes at each stage were contrasted using two-sample Student’s t test. Statistics are represented as heatmaps of t values corresponding to voxel-level P < 0.005 and cluster-level P < 0.05.