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. 2020 May 20;18(4):157–179. doi: 10.1089/adt.2020.970

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© Johan Wernevik et al. 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 8. — (A) Illustration of data obtained in the ATM inhibitor project, separated on neutral compounds (gray filled circle) and bases (brown filled triangle). (A) Potency on primary target reported as the negative logarithm of apparent IC₅₀ values. (B) logD7.4. (C) Logarithm of the aqueous solubility (μM). (D) Logarithm of the fraction unbound (f_u) obtained in the PPB assay. (E) Logarithm of the intrinsic clearance values in human liver microsomes. (F) Logarithm of the intrinsic clearance values in primary rat hepatocytes. The lines in each graph represent the moving average for the compounds (each period defined by 10 compounds). The chemical structures of the published chemical starting point (brown unfilled circle), an optimized lead compound (purple unfilled square) and two candidate drugs (green unfilled triangle, blue unfilled diamond) are provided below the graphs. ATM, Ataxia Telangiectasia Mutated; PPB, plasma protein binding. Color images are available online.