Table 1.
Demographic, clinical, and AD biomarker characteristics over the total sample and per disease group
| SCD Aβ + (n=10) | SCD Aβ-(n=15) | MCI/AD (n = 53) | Total Sample (n = 78) | Total SCD (n = 25) | |
|---|---|---|---|---|---|
| Age, years | 67 ± 6 | 64 ± 6 | 65 ± 7 | 65 ± 7 | 65 ± 6 |
| Female, % | 60% | 60% | 53% | 43% | 60% |
| No. Aß positive subjects | 10(100%) | 0(0%) | 53 (100%) | 63 (81%) | 10 (40%) |
| Education, Verhage scale, median(range) | 6 (4-7) | 6 (2-7) | 6 (3-7) | 6 (2-7) | 6 (2-7) |
| Time lag LP/PET, years | 0.7 ± 0.6 | 0.9 ± 0.5 | 0.6 ± 0.5 | 0.7 ± 0.5 | 0.8 ± 0.7 |
| Neuropsychological measures | |||||
| MMSE (n=78) | 28 ± 1 | 28 ± 1 | 23 ± 4b | 25 ± 4 | 28 ± 1 |
| Memoryc (n=78) | -0.5 ± 0.8 | 0.3 ± 0.6 | -3.1 ± 2.1b | -2.1 ± 2.3 | -0.0 ± 0.8 |
| Attentiond (n=73) | -0.2 ± 0.6 | 0.1 ± 0.6 | -1.3 ± 1.2b | -0.9 ± 1.2 | -0.0 ± 0.6 |
| Languagee (n=68) | -0.0 ± 0.4 | 0.0 ± 0.8 | -1.0 ± 1.0b | -0.6 ± 1.0 | -0.0 ± 0.7 |
| Executive functioningf (n=73) | -0.1 ± 0.9 | -0.1 ± 0.7 | -2.4 ± 1.0b | -0.9 ± 1.1 | 0.0 ± 0.8 |
| Tau biomarkers | |||||
| CSF | |||||
| CSF Aß1-42 | 779 ± 197 | 1067 ± 217 | 541 ± 113b | 677 ± 260 | 966 ± 247 |
| CSF t-tau | 615 ± 383 | 257 ± 201 | 760 ± 412bd | 645 ± 422 | 401 ± 333 |
| CSF p-tau | 83 ± 36 | 43 ± 23 | 90 ± 35b | 80 ± 38 | 59 ± 38 |
| [18F]flortaucipir PET | |||||
| Entorhinal cortex BPND | 0.2 ± 0.2 | -0.1 ± 0.1 | 0.3 ± 0.2b | 0.2 ± 0.2 | -0.0 ± 0.2 |
| Limbic region BPND | 0.2 ± 0.1 | 0.0 ± 0.0 | 0.4 ± 0.2b | 0.3 ± 0.2 | 0.1 ± 0.1 |
| Neocortex BPND | 0.1 ± 0.1 | -0.0 ± 0.0 | 0.3 ± 0.3b | 0.2 ± 0.3 | 0.0 ± 0.1 |
| Entorhinal cortex SUVr | 1.0 ± 0.1 | 1.3 ± 0.2 | 1.5 ± 0.2b | 1.4 ± 0.3 | 1.1 ± 0.2 |
| Limbic region SUVr | 1.1 ± 0.1 | 1.3 ± 0.2 | 1.5 ± 0.2b | 0.4 ± 0.3 | 1.2 ± 0.1 |
| Neocortex SUVr | 1.1 ± 0.1 | 1.2 ± 0.2 | 1.4 ± 0.3b | 1.3 ± 0.3 | 1. ± 0.1 |
Continuous data shown as mean ± standard deviation, unless specified otherwise. Differences in demographic, clinical, and AD biomarker characteristics between disease groups were assessed using ANOVA for continuous variables and χ2 for dichotomous data
aSignificantly different from SCD subjects at p < 0.05. bSignificantly different from SCD subjects at p < 0.01
cZ-score memory domain, dZ-score attention domain, eZ-score language domain, fZ-score executive functioning domain