Table 2.
Standardized ß coefficients for the relationship between CSF p-tau and entorhinal, limbic, and neocortical [18F]flortaucipir BPND or SUVr over the total sample and stratified per disease group
| Total sample (n = 78) |
SCD (n = 25) |
MCI/AD (n = 53) |
|
|---|---|---|---|
| CSF p-tau | CSF p-tau | CSF p-tau | |
| Entorhinal[18F]flortaucipir BPND | 0.46 (p <0.01) | 0.43 (p = 0.07) | 0.17(p = 0.17) |
| Limbic [18F]flortaucipir BPND | 0.45 (p = <0.01) | 0.59a (p = 0.01) | 0.22 (p = 0.08) |
| Neocortical [18F]flortaucipir BPND | 0.43 (p = <0.01) | 0.54 (p = 0.02) | 0.27 (p = 0.03) |
| Entorhinal[18F]flortaucipir SUVr | 0.50 (p = <0.01) | 0.59 (p<0.01) | 0.16 (p = 0.21) |
| Limbic [18F]flortaucipir SUVr | 0.47 (p = <0.01) | 0.67(p = 0.00) | 0.21 (p = 0.09) |
| Neocortical [18F]flortaucipir SUVr | 0.43 (p = <0.01) | 0.41 (p = 0.08) | 0.26 (p = 0.03) |
Standardized ß coefficients (significant in bold) from regression analysis with [18F]flortaucipir BPND or SUVr as the dependent variables and CSF p-tau as predictor.
Effects adjusted for age, sex, and time lag between LP and [18F]flortaucipir PET