Table 1.
Patients’ and tumor characteristics in three treatment groups of local breast cancer recurrence
| Overall | BCS with IORT | Mastectomy | Mastectomy with reconstruction | P value | |
|---|---|---|---|---|---|
| N | 113 | 26 | 35 | 52 | |
| Age at recurrence [years; mean (SD)] | 61.8 (12.7) | 64.6 (11.4) | 69.0 (9.4) | 55.4 (12.2) | < 0.001 |
| Interval from early diagnosis to recurrence [years; mean (SD)] | 10.5 (7.8) | 11.6 (7.0) | 12.3 (8.8) | 8.6 (7.1) | 0.07 |
| Histopathological tumor size (n) | 0.72 | ||||
|
rpT1–2 rpT3–4 rpTx |
91.2% (103) 5.3% (6) 3.5% (4) |
96.2% (25) 3.8% (1) 0% |
88.9% (31) 8.6% (3) 5.4% (1) |
90.4% (47) 3.8% (2) 5.8% (3) |
|
| Histopathological axillary lymph node (n) | 0.01 | ||||
|
rpN0 rpN1–2 rpNx |
46.0% (52) 16.8% (19) 37.2% (42) |
92.3% (24) 7.7% (2) 0% |
22.9% (8) 25.8% (9) 51.4% (18) |
34.5% (18) 17.3% (9) 46.2% (24) |
|
| Tumor grading (n) | 0.30 | ||||
|
Higher differentiated (G1 and G2) Poorly differentiated (G3) Unknown (Gx) |
44.2% (50) 40.7% (46) 15.0% (17) |
61.5% (16) 34.6% (9) 3.8% (1) |
0% (14) 45.7% (16) 14.2% (5) |
38.5% (20) 40.4% (21) 21.2% (11) |
|
| Hormonal receptors (n) | 0.22 | ||||
|
Positive (> 5%) Negative Unknown |
67.3% (76) 28.3% (32) 4.4% (5) |
80.8% (21) 19.2% (5) 0% |
65.7% (23) 22.9% (8) 11.4% (4) |
61.5% (32) 36.5% (19) 1.9% (1) |
|
| Adjuvant chemotherapy (n) | 0.09 | ||||
|
Yes No Unknown |
25.7% (29) 70.8% (80) 3.5% (4) |
11.5% (3) 88.5% (23) 0% |
25.7% (9) 71.4% (25) 2.9% (1) |
30.8% (16) 61.5% (32) 7.7% (4) |
|
| Adjuvant endocrine therapy (n) | 0.08 | ||||
|
Yes No Unknown |
60.2% (68) 36.3% (41) 3.5% (4) |
76.9% (20) 23.1% (6) 0% |
62.9% (22) 31.4% (11) 5.7% (2) |
50.0% (26) 46.2% (24) 3.8% (2) |
|
| Axillary surgery | 0.55 | ||||
|
No axillary surgery Sentinel nodectomy Axillary dissection |
48.7% (55) 38.1% (43) 13.3% (15) |
53.8% (14) 42.3% (11) 3.6% (1) |
51.4% (18) 34.3% (12) 14.3% (5) |
44.2% (23) 38.5% (20) 17.3% (9) |