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. 2020 Aug 10;41(11):3135–3148. doi: 10.1007/s10072-020-04583-3

Table 5.

Application of criteria to literature case reports

Major clinical criteria Minor clinical criteria Major neuroradiological criteria Minor neuroradiological criteria
Headache Cognitive impairment Stroke/TIA Focal neurological deficit Seizure (s) Impaired level of consciousness Psychiatric alterations Multiple MRI lesions Parenchymal or meningeal contrast enhancement MRA abnormalities Vessel wall contrast enhancement on black blood MRI Single MRI lesion Intraparenchymal or subarachnoid hemorrhage Clinical + neuroradiological criteria* Combination (s)
Al Share, 2017 [29] x x C:1 > + N:1 > A
Kumar, 2017 [30] x x x C:1 > +  N:1 >and 1 < A
Takahashi, 2017 [31] x x x x C:1 > and 1 < + N:2 > A
Lee, 2017 [32] x x x x C: 2 > +  N:1 > and 1 < A & B
Arif, 2017 [33] x x x C:1 > and 1 < + N:1 > A
Mizuno, 2016 [34] x x x C:1 > +  N:2 > A
Sun, 2016 [35] x x x x C: 2 > and 1 < + N:1 < B
Benson, 2016 [36] x x x C:2 > + N:1 > A
Pillai, 2016 [37] x x x C:2 > + N:1 > A
Fang, 2015 [38] x x x x x C:1 > and 1 < + N:2 > and 1 < A & B
Kim, 2015 [39] x X x x C:2 < + N:2 > A
Bajaj, 2015 [40] x x x x C:1 > and 1 < + N:2 > A
Kim SI, 2015 [41] x x x C:1 < + N:1 > and 1 < A
Killeen, 2015 [42] x x x x x C:3 > + N:1 > and 1 < A & B
Gan, 2015 [43] x x x x C:2 > + N:1 > and 1 < A & B
Huang, 2015 [44] x x x x C:2 > + N:2 > A
Okunomiya, 2014 [45] x x x C:1 > + N:2 > A
Safouris, 2014 [46] x x x C:2 > + N:1 > A
Michiels, 2014 [47] x x x x x C:2 > and 1 < + N:1 > and 1 < A & B
Gaillard, 2014 [48] x x x C:1 > + N:2 > A
Rao, 2014 [49] x x x C:1 > + N:2 > A
Noh, 2014 [50] x x x x x C:2 > + N:3 > A
Safouris, 2013 [46] x x x C:2 > + N:1 > A
Orr, 2013 [51] x x x x C:2 > + N:2 > A
Lyra, 2013 [52] x x x x C:1 > + N:2 > and 1 < A
Rosenberg, 2013 [53] x x x C:1 > + N: 2 > A
Okeda, 2012 [54] x x x C:1 < + N:2 > A
Yu, 2011 [55] x x x x C:2 > and 1 < + N:1 > A
Ghavanini, 2011 [56] x x x x C:1 > and 1 < + N:1 > and 1 < A & B
Ho, 2011 [57] x x x x C:1 > and 1 < + N:2 > A
Tanei, 2011 [58] x x x C:1 > + N:2 > A
Pires, 2011 [59] x x C:1 > + N:1 > A

*C number of major (>) or minor (<) clinical criteria present; N = number of major (>) or minor (<) neuroradiological criteria present

Combination ‘A’: One clinical (major or minor) + one major neuroradiological feature

Combination ‘B’: Two clinical (at least one major) + one minor neuroradiological feature